Molecular epidemiology of measles viruses in China, 1995–2003Report as inadecuate

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Virology Journal

, 4:14

First Online: 05 February 2007Received: 27 January 2007Accepted: 05 February 2007


This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%–100% and 93.3%–100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China.

List of abbreviationsMVMeasles virus

RT-PCRreverse transcriptase polymerase chain reaction



WHOWorld Health Organization

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-4-14 contains supplementary material, which is available to authorized users.

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Author: Yan Zhang - Zhen Zhu - Paul A Rota - Xiaohong Jiang - Jiayu Hu - Jianguo Wang - Wei Tang - Zhenying Zhang - Congyong Li


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