Recurrence of nephrotic syndrome-focal segmental glomerulosclerosis following renal transplantation in childrenReportar como inadecuado




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Pediatric Nephrology

, Volume 22, Issue 4, pp 496–502

First Online: 21 December 2006Received: 20 June 2006Revised: 24 August 2006Accepted: 28 August 2006

Abstract

The incidence of recurrence of nephrotic syndrome-focal segmental glomerulosclerosis NS-FSGS is variable ~30%

The incidence of recurrence is less in African-Americans than in whites and Hispanics

Graft survival rates are decreased in recipients with FSGS, especially if remission of the NS is not achieved in those with recurrence

Although controversial, the use of living donor LD transplants are not contraindicated; however, obligatory heterozygote parental grafts with a podocin mutation should be used with caution

Optimal treatment to induce a remission post-transplant has not been delineated

Pre-transplant and-or prophylactic post-transplant pre-operative plasmapheresis PP for high-risk patients—especially those with recurrence in a previous graft—may be promising

An international multicenter controlled study is required to delineate the optimal approach to prevent and-or treat the recurrence of NS-FSGS

KeywordsRecurrent focal segmental glomerulosclerosis FSGS Plasmapheresis Nephrectomy Immunosuppressive medications Long-term outcome  Download fulltext PDF



Autor: Richard N. Fine

Fuente: https://link.springer.com/







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