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Pediatric Nephrology

, Volume 22, Issue 5, pp 638–644

First Online: 09 March 2007Received: 25 August 2006Revised: 18 December 2006Accepted: 09 January 2007

Abstract

The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis FSGS and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic studies. Those genes and proteins interactions seem to change susceptibility to kidney disease progression. Better understanding of their exact role in the development of FSGS may influence future therapies and outcomes in this complex disease.

KeywordsGene mutations Filtration barrier Linkage analysis Positional cloning  Download fulltext PDF



Autor: Robert P. Woroniecki - Jeffrey B. Kopp

Fuente: https://link.springer.com/



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