Molecular analysis of human endometrium: short-term tibolone signaling differs significantly from estrogen and estrogen progestagen signalingReportar como inadecuado




Molecular analysis of human endometrium: short-term tibolone signaling differs significantly from estrogen and estrogen progestagen signaling - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Molecular Medicine

, Volume 85, Issue 5, pp 471–480

First Online: 17 January 2007Received: 31 August 2006Revised: 13 November 2006Accepted: 23 November 2006

Abstract

Tibolone, a tissue-selective compound with a combination of estrogenic, progestagenic, and androgenic properties, is used as an alternative for estrogen or estrogen plus progesterone hormone therapy for the treatment of symptoms associated with menopause and osteoporosis. The current study compares the endometrial gene expression profiles after short-term 21 days treatment with tibolone to the profiles after treatment with estradiol-only E2 and E2 + medroxyprogesterone acetate E2 + MPA in healthy postmenopausal women undergoing hysterectomy for endometrial prolapse. The impact of E2 treatment on endometrial gene expression 799 genes was much higher than the effect of tibolone 173 genes or E2 + MPA treatment 174 genes. Furthermore, endometrial gene expression profiles after tibolone treatment show a weak similarity to the profiles after E2 treatment overlap 72 genes and even less profile similarity to E2 + MPA treatment overlap 17 genes. Interestingly, 95 tibolone-specific genes were identified. Translation of profile similarity into biological processes and pathways showed that ER-mediated downstream processes, such as cell cycle and cell proliferation, are not affected by E2 + MPA, slightly by tibolone, but are significantly affected by E2. In conclusion, tibolone treatment results in a tibolone-specific gene expression profile in the human endometrium, which shares only limited resemblance to E2 and even less resemblance to E2 + MPA induced profiles.

KeywordsTibolone Endometrium Hormone replacement therapy Estrogen Progestagen Gene expression profiling  Download fulltext PDF



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Fuente: https://link.springer.com/







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