Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicksReportar como inadecuado




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BMC Neuroscience

, 8:37

First Online: 31 May 2007Received: 05 March 2007Accepted: 31 May 2007

Abstract

BackgroundCarnosine β-alanyl-L-histidine is a putative neurotransmitter and has a possible role in neuron-glia cell interactions. Previously, we reported that carnosine induced hyperactivity in chicks when intracerebroventricularly i.c.v. administered. In the present study, we focused on other β-alanyl dipeptides to determine if they have novel functions.

ResultsIn Experiment 1, i.c.v. injection of β-alanyl-L-leucine, but not β-alanyl-glycine, induced hyperactivity behavior as observed with carnosine. Both carnosine and β-alanyl-L-leucine stimulated corticosterone release. Thus, dipeptides of β-alanyl-branched chain amino acids were compared in Experiment 2. The i.c.v. injection of β-alanyl-L-isoleucine caused a similar response as β-alanyl-L-leucine, but β-alanyl-L-valine was somewhat less effective than the other two dipeptides. β-Alanyl-L-leucine strongly stimulated, and the other two dipeptides tended to stimulate, corticosterone release.

ConclusionThese results suggest that central β-alanyl-branched chain amino acid stimulates activity in chicks through the hypothalamus-pituitary-adrenal axis. We named β-alanyl-L-leucine, β-alanyl-L-isoleucine and β-alanyl-L-valine as Excitin-1, Excitin-2 and Excitin-3, respectively.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2202-8-37 contains supplementary material, which is available to authorized users.

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Autor: Yousuke Tsuneyoshi - Shozo Tomonaga - Mari Asechi - Koji Morishita - D Michael Denbow - Mitsuhiro Furuse

Fuente: https://link.springer.com/







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