TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French populationReportar como inadecuado

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medical Genetics

, 8:37

First Online: 25 June 2007Received: 27 February 2007Accepted: 25 June 2007


BackgroundIn adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes T2D, has been also associated with a lower body mass index BMI in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance.

MethodsThe present association study aimed at analyzing the contribution of the rs7903146 SNP to smallness for gestational age SGA and metabolic profiles in subjects with SGA or appropriate for gestational age birth weight AGA. Two groups of French Caucasian subjects were selected on birth data: SGA birth weight < 10 percentile; n = 764, and AGA 25 < birth weight < 75 percentile; n = 627. Family-based association tests were also performed in 3,012 subjects from 628 SGA and AGA pedigrees.

ResultsThe rs7903146 genotypic distributions between AGA 30.7% and SGA 29.0% were not statistically different allelic OR = 0.92 0.78–1.09, p = 0.34. Family association-based studies did not show a distortion of T allele transmission in SGA subjects p = 0.52. No significant effect of the T allele was detected on any of the metabolic parameters in the SGA group. However, in the AGA group, trends towards a lower insulin secretion p = 0.03 and a higher fasting glycaemia p = 0.002 were detected in carriers of the T allele.

ConclusionThe TCF7L2 rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA.

AbbreviationsT2DType 2 diabetes

BMIBody mass index

SGASmallness for gestational age

AGAAppropriate for gestational age birth weight

OROdds ratio

HOMAHomeostasis model assessment

BWBirth weight

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2350-8-37 contains supplementary material, which is available to authorized users.

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Autor: Stéphane Cauchi - David Meyre - Hélène Choquet - Samia Deghmoun - Emmanuelle Durand - Stefan Gaget - Cécile Lecoeur - P


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