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Virology Journal

, 4:131

First Online: 04 December 2007Received: 08 October 2007Accepted: 04 December 2007

Abstract

Lytic bacteriophage 0305φ8-36 forms visually observed aggregates during plaque formation. Aggregates intrinsically lower propagation potential. In the present study, the following observations indicate that lost propagation potential is regained with time: 1 Aggregates sometimes concentrate at the edge of clear plaques. 2 A semi-clear ring sometimes forms beyond the plaques. 3 Formation of a ring is completely correlated with the presence of aggregates at the same angular displacement along the plaque edge. To explain this aggregate-derived lowering-raising of propagation potential, the following hypothesis is presented: Aggregation-dissociation of bacteriophage of 0305φ8-36 is a selected phenomenon that evolved to maintain high host finding rate in a trade-off with maintaining high rate of bacteriophage progeny production. This hypothesis explains ringed plaque morphology observed for other bacteriophages and predicts that aggregates will undergo time-dependent change in structure as propagation potential increases. In support, fluorescence microscopy reveals time-dependent change in the distance between resolution-limited particles in aggregates.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-4-131 contains supplementary material, which is available to authorized users.

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Autor: Philip Serwer - Shirley J Hayes - Karen Lieman

Fuente: https://link.springer.com/



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