Trafficking of central opioid receptors and descending pain inhibitionReportar como inadecuado

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Molecular Pain

, 3:37

First Online: 04 December 2007Received: 04 September 2007Accepted: 04 December 2007


The delta-opioid receptor DOR belongs to the superfamily of G-protein-coupled receptors GPCRs with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes involving its C-tail motifs, intracellular sorting proteins, and several intracellular signaling pathways. In the quiescent state, DOR is generally located in the intracellular compartments in central neurons. However, chronic stimulation, such as chronic pain and sustained opioid exposure, may induce membrane trafficking of DOR and its translocation to surface membrane. The emerged functional DOR on cell membrane is actively involved in pain modulation and opioid analgesia. This article reviews current understanding of the mechanisms underlying GPCRs and DOR membrane trafficking, and the analgesic function of emerged DOR through membrane trafficking under certain pathophysiological circumstances.

Electronic supplementary materialThe online version of this article doi:10.1186-1744-8069-3-37 contains supplementary material, which is available to authorized users.

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Autor: Bihua Bie - Zhizhong Z Pan


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