Broad network-based predictability of Saccharomyces cerevisiaegene loss-of-function phenotypesReportar como inadecuado

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Genome Biology

, 8:R258

First Online: 05 December 2007Received: 24 July 2007Revised: 16 October 2007Accepted: 05 December 2007


We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available

AbbreviationsAUCarea under the curve

CVcoefficient of variance

DIPDatabase of Interacting Proteins

FNfalse negative

FPfalse positive


GOGene Ontology

MIPSMunich Information Center for Protein Sequences

OMIMOnline Mendelian Inheritance in Man

PICOProbabilistic Integrated Co-complex

ROCreceiver operating characteristic

SCMDS. cerevisiae Morphology Database

SGDSaccharomyces Genome Database

TNtrue negative

TPtrue positive.

Electronic supplementary materialThe online version of this article doi:10.1186-gb-2007-8-12-r258 contains supplementary material, which is available to authorized users.

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Autor: Kriston L McGary - Insuk Lee - Edward M Marcotte


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