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Lipids in Health and Disease

, 5:2

First Online: 23 January 2006Received: 30 November 2005Accepted: 23 January 2006


BackgroundThe heart is rich in cardiolipin, a phospholipid acylated in four sites, predominately with linoleic acid. Whether or not aging alters the composition of cardiolipin acyl chains is controversial. We therefore measured the fatty acid concentration of cardiolipin in hearts of 4, 12 and 24 month old rats that consumed one diet, adequate in fatty acids for the duration of their life.

ResultsThe concentration nmol-g of linoleic acid was decreased in 24 month old rats 3965 ± 617, mean ± SD vs 4 month old rats 5525 ± 656, while the concentrations of arachidonic and docosahexaenoic acid were increased in 24 month old rats 79 ± 9 vs 178 ± 27 and 104 ± 16 vs 307 ± 68 for arachidonic and docosahexaenoic acids, 4 months vs 24 months, respectively. Similar changes were not observed in ethanolamine glycerophospholipids or plasma unesterified fatty acids, suggesting specificity of these effects to cardiolipin.

ConclusionThese results demonstrate that cardiolipin remodeling occurs with aging, specifically an increase in highly unsaturated fatty acids.

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Autor: Ho-Joo Lee - Jana Mayette - Stanley I Rapoport - Richard P Bazinet


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