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Health and Quality of Life Outcomes

, 4:5

First Online: 24 January 2006Received: 18 October 2005Accepted: 24 January 2006


BackgroundFemale patients with cystic fibrosis CF have consistently poorer survival rates than males across all ages. To determine if gender differences exist in health-related quality of life HRQOL of adolescent patients with CF, we performed a cross-section analysis of CF patients recruited from 2 medical centers in 2 cities during 1997–2001.

MethodsWe used the 87-item child self-report form of the Child Health Questionnaire to measure 12 health domains. Data was also collected on age and forced expiratory volume in 1 second FEV1. We analyzed data from 98 subjects and performed univariate analyses and linear regression or ordinal logistic regression for multivariable analyses.

ResultsThe mean SD age was 14.6 2.5 years; 50 51.0% were female; and mean FEV1 was 71.6% 25.6% of predicted. There were no statistically significant gender differences in age or FEV1. In univariate analyses, females reported significantly poorer HRQOL in 5 of the 12 domains. In multivariable analyses controlling for FEV1 and age, we found that female gender was associated with significantly lower global health p < 0.05, mental health p < 0.01, and general health perceptions p < 0.05 scores.

ConclusionFurther research will need to focus on the causes of these differences in HRQOL and on potential interventions to improve HRQOL of adolescent patients with CF.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7525-4-5 contains supplementary material, which is available to authorized users.

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Autor: Renata Arrington-Sanders - Michael S Yi - Joel Tsevat - Robert W Wilmott - Joseph M Mrus - Maria T Britto


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