Microwave-Accelerated and Metal-Enhanced Fluorescence Myoglobin Detection on Silvered Surfaces: Potential Application to Myocardial Infarction DiagnosisReportar como inadecuado




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Plasmonics

, Volume 1, Issue 1, pp 53–59

First Online: 01 March 2006Received: 28 December 2005Accepted: 04 January 2006

Abstract

In this short paper, we describe a novel approach to both significantly accelerate and optically amplify fluorescence-based immunoassays. Our approach utilizes metal-enhanced fluorescence MEF to intrinsically optically amplify fluorescence signatures, which, when combined with the use of low-power microwaves to kinetically accelerate assays, provides for both ultrafast and ultrabright immunoassays. Surprisingly, the use of low-power microwaves and silver nanostructures provides for localized heating, concentrating the effect to the particles themselves as compared to the generic heating of the high dielectric assay fluid. We have subsequently applied our microwave-accelerated MEF approach to the detection of myoglobin, where its rapid quantification is paramount for the clinical assessment of an acute myocardial infarction.

KeywordsMetal-enhanced fluorescence Radiative decay engineering Surface-enhanced fluorescence Low-power microwaves Immunoassays Ultrasensitive and ultrafast clinical assays Myoglobin Myocardial infarction AbbreviationsAMIacute myocardial infarction

SiFssilver-island films

SEFsurface-enhanced fluorescence

MAMEFmicrowave-accelerated metal-enhanced fluorescence

MEFmetal-enhanced fluorescence

Mwlow-power microwaves

Myomyoglobin

RDEradiative decay engineering

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Autor: Kadir Aslan - Chris D. Geddes

Fuente: https://link.springer.com/



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