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International Journal of Peptide Research and Therapeutics

, Volume 12, Issue 1, pp 33–48

First Online: 14 March 2006Received: 22 August 2005

Abstract

Aberrant signaling through protein-tyrosine kinase PTK-dependent pathways is associated with several proliferative diseases. Accordingly, PTK inhibitors are being developed as new approaches for the treatment of certain cancers. Growth factor receptor bound protein 2 Grb2 is an important downstream mediator of PTK signaling that serves obligatory roles in many pathogenic processes. One of the primary functions of Grb2 is to bind to specific phosphotyrosyl pTyr-containing sequences through its Src homology 2 SH2 domain. Agents that bind to the Grb2 SH2 domain and prevent its normal function could disrupt associated PTK signaling and serve as alternatives to kinase-directed inhibitors. Starting from the X-ray crystal structure of a lead peptide bound to the Grb2 SH2 domain, this review will summarize important contributions to these efforts. The presentation will be thematically arranged according to the region of peptide modified, proceeding from the N-terminus to the C-terminus, with a special section devoted to aspects of conformational constraint.

KeywordsGrb2 peptide mimetic phosphotyrosyl SH2 domain signaling inhibitor AbbreviationsEGFRepidermal growth factor receptor

Grb2growth factor receptor bound protein 2

HGFhepatocyte growth factor

pTyrphosphotyrosyl

PTKprotein-tyrosine kinase

RCMring closing metathesis

SH2Src homology 2

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Autor: Terrence R. Burke Jr

Fuente: https://link.springer.com/







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