Inhalation of β2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tractReportar como inadecuado




Inhalation of β2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Respiratory Research

, 7:57

First Online: 04 April 2006Received: 29 January 2006Accepted: 04 April 2006

Abstract

BackgroundNontypable Haemophilus influenzae NTHi is a common bacterial pathogen causing human respiratory tract infections under permissive conditions such as chronic obstructive pulmonary disease. Inhalation of β2-receptor agonists is a widely used treatment in patients with chronic obstructive pulmonary disease. The aim of this study was to determine the effect of inhalation of β2 agonists on the host immune response to respiratory tract infection with NTHi.

MethodsMouse alveolar macrophages were stimulated in vitro with NTHi in the presence or absence of the β2 receptor agonists salmeterol or salbutamol. In addition, mice received salmeterol or salbutamol by inhalation and were intranasally infected with NTHi. End points were pulmonary inflammation and bacterial loads.

ResultsBoth salmeterol and salbutamol inhibited NTHi induced tumor necrosis factor-α TNFα release by mouse alveolar macrophages in vitro by a β receptor dependent mechanism. In line, inhalation of either salmeterol or salbutamol was associated with a reduced early TNFα production in lungs of mice infected intranasally with NTHi, an effect that was reversed by concurrent treatment with the β blocker propranolol. The clearance of NTHi from the lungs was impaired in mice treated with salmeterol or salbutamol, an adverse effect that was prevented by propranolol and independent of the reduction in TNFα.

ConclusionThese data suggest that inhalation of salmeterol or salbutamol may negatively influence an effective clearance of NTHi from the airways.

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Autor: Nico A Maris - Sandrine Florquin - Cornelis van-t Veer - Alex F de Vos - Wim Buurman - Henk M Jansen - Tom van der Poll

Fuente: https://link.springer.com/



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