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Virology Journal

, 3:24

First Online: 04 April 2006Received: 22 December 2005Accepted: 04 April 2006

Abstract

BackgroundThe bioinformatic prediction of protein subcellular localization has been extensively studied for prokaryotic and eukaryotic organisms. However, this is not the case for viruses whose proteins are often involved in extensive interactions at various subcellular localizations with host proteins.

ResultsHere, we investigate the extent of utilization of human cellular localization mechanisms by viral proteins and we demonstrate that appropriate eukaryotic subcellular localization predictors can be used to predict viral protein localization within the host cell.

ConclusionSuch predictions provide a method to rapidly annotate viral proteomes with subcellular localization information. They are likely to have widespread applications both in the study of the functions of viral proteins in the host cell and in the design of antiviral drugs.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-3-24 contains supplementary material, which is available to authorized users.

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Autor: MS Scott - R Oomen - DY Thomas - MT Hallett

Fuente: https://link.springer.com/



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