La cuerda dulce – a tolerability and acceptability study of a novel approach to specimen collection for diagnosis of paediatric pulmonary tuberculosisReportar como inadecuado




La cuerda dulce – a tolerability and acceptability study of a novel approach to specimen collection for diagnosis of paediatric pulmonary tuberculosis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Infectious Diseases

, 6:67

First Online: 04 April 2006Received: 20 December 2005Accepted: 04 April 2006

Abstract

BackgroundRecent data demonstrate the utility of the string test for the diagnosis of sputum-scarce HIV-associated TB in adults. We hypothesized that, if well-tolerated by children, this simple tool might offer a breakthrough in paediatric TB diagnosis. Thus the objective of this study, undertaken in the paediatric service of the Hospital Nacional Dos de Mayo, Lima, Perú, was to determine the tolerability and acceptability of the string test to paediatric TB suspects, their parents and nursing staff.

Methods22 paediatric subjects aged 3–14 years median 8 under investigation for TB were invited to undergo 2 string tests four-hour downtime each. Subjective and objective pain and discomfort rating scales were used to assess the perception of the subject, parent and attending nurse.

ResultsPatients as young as 4 years tolerated the procedure extremely well with 84% willing to undergo a second procedure. Peak discomfort at the time of swallowing and of string retrieval was mild 30% of maximum possible score and brief as judged by visual analogue ratings and objective indicators. Good concordance of parent-child and objective-subjective ratings strengthened the validity of these findings.

ConclusionThe string test is well tolerated and achievable for most paediatric TB suspects as young as 4 years. A formal prospective paediatric efficacy study is now needed.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-6-67 contains supplementary material, which is available to authorized users.

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Autor: Felicia Chow - Nora Espiritu - Robert H Gilman - Rosmery Gutierrez - Sonia Lopez - A Roderick Escombe - Carlton AW Evans

Fuente: https://link.springer.com/







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