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BMC Bioinformatics

, 7:366

First Online: 28 July 2006Received: 18 May 2006Accepted: 28 July 2006


BackgroundIn the Bioinformatics field, a great deal of interest has been given to Non-negative matrix factorization technique NMF, due to its capability of providing new insights and relevant information about the complex latent relationships in experimental data sets. This method, and some of its variants, has been successfully applied to gene expression, sequence analysis, functional characterization of genes and text mining. Even if the interest on this technique by the bioinformatics community has been increased during the last few years, there are not many available simple standalone tools to specifically perform these types of data analysis in an integrated environment.

ResultsIn this work we propose a versatile and user-friendly tool that implements the NMF methodology in different analysis contexts to support some of the most important reported applications of this new methodology. This includes clustering and biclustering gene expression data, protein sequence analysis, text mining of biomedical literature and sample classification using gene expression. The tool, which is named bioNMF, also contains a user-friendly graphical interface to explore results in an interactive manner and facilitate in this way the exploratory data analysis process.

ConclusionbioNMF is a standalone versatile application which does not require any special installation or libraries. It can be used for most of the multiple applications proposed in the bioinformatics field or to support new research using this method. This tool is publicly available at

AbbreviationsNMFNon-negative Matrix Factorization

PCAPrincipal Component Analysis

SVDSingular Value Decomposition

ICAIndependent Component Analysis

ns NMFNon-Smooth Non-negative Matrix Factorization

AMLAcute Myelogenous Leukemia

ALLAcute Lymphoblastic Leukemia

GUIGraphical User Interface

GOGene Ontology

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2105-7-366 contains supplementary material, which is available to authorized users.

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Autor: Alberto Pascual-Montano - Pedro Carmona-Saez - Monica Chagoyen - Francisco Tirado - Jose M Carazo - Roberto D Pascual-Marq


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