Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control studyReportar como inadecuado




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BMC Medical Genetics

, 7:67

First Online: 31 July 2006Received: 18 May 2006Accepted: 31 July 2006

Abstract

BackgroundChronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms AAAs. The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms.

MethodsHLA-DQA1 -DQB1 -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases 180 Belgian and 207 Canadian and 426 controls 269 Belgian and 157 Canadian by a PCR and single-strand oligonucleotide probe hybridization assay.

ResultsWe observed a potential association with the HLA-DQA1 locus among Belgian males empirical p = 0.027, asymptotic p = 0.071. Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases 67-322 alleles, 20.8% and controls 44-356 alleles, 12.4% in Belgian males empirical p = 0.019, asymptotic p = 0.003. In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics.

ConclusionThis study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.

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Autor: Toru Ogata - Lucie Gregoire - Katrina AB Goddard - Magdalena Skunca - Gerard Tromp - Wayne D Lancaster - Antonio R Parra

Fuente: https://link.springer.com/







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