Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCGMoreau Rio de Janeiro RDJ in healthy adultsReportar como inadecuado

Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCGMoreau Rio de Janeiro RDJ in healthy adults - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Immune Based Therapies and Vaccines

, 4:4

First Online: 06 September 2006Received: 31 October 2005Accepted: 06 September 2006


BackgroundOral administration of BCG was the route initially used by Calmette and Guérin, but was replaced by intradermal administration in virtually all countries after the Lubeck accident. However, Brazil continued to administer oral BCG Moreau RDJ, which was maintained until the mid-1970s when it was substituted by the intradermal route. Although BCG vaccination has been used in humans since 1921, little is known of the induced immune response. The aim of this study was to analyse immunological responses after oral vaccination with M. bovis BCG Moreau RDJ.

MethodsThis study in healthy volunteers has measured cellular and humoral aspects of the immunological response to oral M. bovis BCG Moreau RDJ in Rio de Janeiro, Brazil. T-cell trafficking and Th1 and Th2 cytokine responses are described, as well as isotype-specific antibody production using novel techniques.

ResultsOral immunisation has no adverse effects. We have shown that there are cellular and humoral immunological responses after oral immunisation. Oral revaccination does not induce a positive skin test in responsive individuals and multiple booster orally was able to induce modulation in humoral immunological responses switch from IgG to IgA in previously immunised subjects and incapable of inducing tolerance. In contrast, the cellular immune response does not differ between vaccinated individuals with positive and negative skin test reactions.

ConclusionAll subjects, including those who did not respond to the skin test at study commencement, were capable of mounting humoral and cellular immune response to the antigens tested.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-8518-4-4 contains supplementary material, which is available to authorized users.

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Autor: Renata Monteiro-Maia - Maria B Ortigão-de-Sampaio - Rosa T Pinho - Luiz RR Castello-Branco


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