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Genome Biology

, 7:R89

First Online: 09 October 2006Received: 31 May 2006Revised: 26 July 2006Accepted: 09 October 2006


BackgroundGene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become more tissue specific. We explored the relationship between duplication events, the time at which they took place, and both the expression breadth of the duplicated genes and the cumulative expression breadth of the gene family to which they belong.

ResultsWe show that only duplicates that arose through post-multicellularity duplication events show a tendency to become more specifically expressed, whereas such a tendency is not observed for duplicates that arose in a unicellular ancestor. Unlike the narrow expression profile of the duplicated genes, the overall expression of gene families tends to maintain a global expression pattern.

ConclusionThe work presented here supports the view suggested by the subfunctionalization model, namely that expression divergence in different tissues, following gene duplication, promotes the retention of a gene in the genome of multicellular species. The global expression profile of the gene families suggests division of expression between family members, whose expression becomes specialized. Because specialization of expression is coupled with an increased rate of sequence divergence, it can facilitate the evolution of new, tissue-specific functions.

Electronic supplementary materialThe online version of this article doi:10.1186-gb-2006-7-10-r89 contains supplementary material, which is available to authorized users.

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Autor: Shiri Freilich - Tim Massingham - Eric Blanc - Leon Goldovsky - Janet M Thornton


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