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Clinical Research in Cardiology

, Volume 95, Issue 11, pp 569–583

Whom to biopsy in suspected myocarditis?First Online: 16 August 2006Received: 02 January 2006Accepted: 27 June 2006 Summary

The role of endomyocardial biopsies in patients with clinically suspected acute myocarditis, myocarditis in the past, and dilated cardiomyopathy is discussed controversially. In fact, it is still under discussion whether information obtained from endomyocardial biopsies is relevant for further clinical decisions. Therefore this Critical Perspective will deal with the question, which patient should undergo endomyocardial biopsy investigations for an etiopathogenic differentiation of the disease and for the possible choice of immunomodulatory treatment strategies.

Key wordsEndomyocardial biopsy myocarditis dilated cardiomyopathy inflammatory cardiomyopathy viral infection AbbreviationsBICC-TrialBetaferon in Chronic Viral Cardiomyopathy

CKCreatinine kinase

DCMDilated cardiomyopathy

DCMiInflammatory cardiomyopathy


EMBEndomyocardial biopsy

LVLeft ventricle

PCRPolymerase chain reaction

TIMPTissue inhibitors of matrix metalloproteinases

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Autor: M. Pauschinger - M. Noutsias - D. Lassner - H.-P. Schultheiss - U. Kuehl


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