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1 Laboratoire d-Informatique, Signaux, et Systèmes de Sophia-Antipolis I3S - Equipe SIGNAL SIS - Signal, Images et Systèmes 2 Nalecz Institute of Biocybernetics and Biomedical Engineering 3 Warsaw Education Center CVG Medtronic Poland 4 National Institute of Cardiology

Abstract : New statistical and spectral detectors, the modified matched pairs t-test, the extended spectral method and the modified spectral method, was proposed for T-wave alternans TWA detection gaining robustness according to trend and single frequency interferences. They were compared to classic detectors such as matched pairs t-test, unpaired t-test, spectral method, generalized likelihood ratio test and estimated TWA amplitude within a simulation framework and applied to real data. The optimal detection threshold was selected by using a full Monte-Carlo simulation where signals, with and without alternans episodes, were corrupted by Gaussian noise with different power and single frequency interferences with different tones. All the combinations of noise and frequency were selected and repeated 500 times in order to compute probability of detection Pd and the false alarm probability Pfa, providing ROC curves. The study group consisted of 50 patients with implantable cardioverter-defibrillator age: 55.3 +-16.4; LVEF: 42.8 +-15.5, who were paced ventricular pacing at 100 bpm. Two-minute recordings were analyzed. The XYZ orthogonal lead system was used. The best performance was reached by using the modified matched pairs t-test in comparison with the spectral method and other reference methods.

Keywords : detector T wave alternans ECG

Autor: Olivier Meste - Darius Janusek - S Karczmarewicz - A Przybylski - Michal Kania - A Maciag - Roman Maniewski -



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