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World Journal of Surgical Oncology

, 3:6

First Online: 31 January 2005Received: 14 December 2004Accepted: 31 January 2005

Abstract

BackgroundPlexiform neurofibromas PNF are benign tumors of the peripheral nerve which mostly develop in patients with neurofibromatosis type 1 NF1. Surgical interventions are usually not applied to children with small tumors. These are rather restricted to debulking of larger tumors in adults that cause clinical complications or aesthetic disfigurement. In most cases, a total resection of PNF is not possible due to the network-like growth of the tumors.

Patients and methodsEarly surgical intervention was carried out for 9 small PNFs in 7 NF1 children. Tumor resection was performed following the graphical delineation of the affected skin and according the MRI findings.

ResultsTotal resection was achieved for all 9 PNF without causing any neurological or organic deficit. Annual magnetic resonance tomography over a period of four years did not reveal any relapse of the tumors.

ConclusionsEarly surgical intervention for small superficial PNFs in NF1 children have various advantages and may especially be considered a strategy to prevent progression.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7819-3-6 contains supplementary material, which is available to authorized users.

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Autor: Reinhard E Friedrich - Rainer Schmelzle - Melanie Hartmann - Carsten Fünsterer - Victor-F Mautner

Fuente: https://link.springer.com/







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