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Cell Communication and Signaling

, 3:1

First Online: 31 January 2005Received: 21 July 2004Accepted: 31 January 2005


BackgroundThe ciliary neurotrophic factor CNTF receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor α component CNTFR. This tripartite receptor has been shown to play important roles in the development of motor neurons, but the identity of the relevant ligands is still not clearly established. Recently, we have identified two new ligands for the CNTF receptor complex. These are heterodimeric cytokines composed of cardiotrophin-like cytokine CLC associated either with the soluble receptor subunit cytokine-like factor-1 CLF or the soluble form of the binding receptor itself sCNTFR.

ResultsHere we show that, during development, clc is expressed in lung, kidney, vibrissae, tooth, epithelia and muscles during the period of development corresponding to when motoneuron loss is observed in mice lacking a functional CNTF receptor. In addition, we demonstrate that it is co-expressed at the single cell level with clf and cntfr, supporting the idea that CLC might be co-secreted with either CLF or sCNTFR.

ConclusionThis expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development.

Electronic supplementary materialThe online version of this article doi:10.1186-1478-811X-3-1 contains supplementary material, which is available to authorized users.

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Autor: Béatrice de Bovis - Damien Derouet - Jean-François Gauchat - Greg Elson - Hugues Gascan - Odile deLapeyrière


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