Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidneyReportar como inadecuado




Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Pharmacology

, 5:2

First Online: 31 January 2005Received: 22 July 2004Accepted: 31 January 2005

Abstract

BackgroundCCl4 is a well-established hepatotoxin inducing liver injury by producing free radicals. Exposure to CCl4 also induces acute and chronic renal injuries. The present study was designed to establish the protective effect of hesperidin HDN, a citrus bioflavonoid, on CCl4-induced oxidative stress and resultant dysfunction of rat liver and kidney.

MethodsAnimals were pretreated with HDN 100 and 200 mg-kg orally for one week and then challenged with CCl4 2 ml-kg-s.c. in olive oil. Rats were sacrificed by carotid bleeding under ether anesthesia. Liver enzymes, urea and creatinine were estimated in serum. Oxidative stress in liver and kidney tissue was estimated using Thiobarbituric acid reactive substances TBARS, glutathione GSH content, superoxide dismutaseSOD, and Catalase CAT

ResultsCCl4 caused a marked rise in serum levels of ALT and AST P < 0.05. TBARS levels were significantly increased whereas GSH, SOD and CAT levels decreased in the liver and kidney homogenates of CCl4 treated rats. HDN 200 mg-kg successfully attenuated these effects of CCl4

ConclusionIn conclusion, our study demonstrated a protective effect of HDN in CCl4 induced oxidative stress in rat liver and kidney. This protective effect of HDN can be correlated to its direct antioxidant effect.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2210-5-2 contains supplementary material, which is available to authorized users.

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Autor: Naveen Tirkey - Sangeeta Pilkhwal - Anurag Kuhad - Kanwaljit Chopra

Fuente: https://link.springer.com/







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