Genomic analysis of early murine mammary gland development using novel probe-level algorithmsReportar como inadecuado




Genomic analysis of early murine mammary gland development using novel probe-level algorithms - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Genome Biology

, 6:R20

First Online: 01 February 2005Received: 25 August 2004Revised: 01 October 2004Accepted: 08 December 2004

Abstract

We describe a novel algorithm ChipStat for detecting gene-expression changes utilizing probe-level comparisons of replicate Affymetrix oligonucleotide microarray data. A combined detection approach is shown to yield greater sensitivity than a number of widely used methodologies including SAM, dChip and logit-T. Using this approach, we identify alterations in functional pathways during murine neonatal-pubertal mammary development that include the coordinate upregulation of major urinary proteins and the downregulation of loci exhibiting reciprocal imprinting.

Electronic supplementary materialThe online version of this article doi:10.1186-gb-2005-6-2-r20 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Stephen R Master - Alexander J Stoddard - L Charles Bailey - Tien-Chi Pan - Katherine D Dugan - Lewis A Chodosh

Fuente: https://link.springer.com/







Documentos relacionados