The value of PET, CT and in-line PET-CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylateReportar como inadecuado




The value of PET, CT and in-line PET-CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylate - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 32, Issue 2, pp 153–162

First Online: 04 September 2004Received: 15 January 2004Accepted: 16 June 2004

Abstract

PurposeGastrointestinal stromal tumours GIST are mesenchymal neoplasms of the gastrointestinal tract that are unresponsive to standard sarcoma chemotherapy. Imaging of GIST patients is done with structural and functional methods such as contrast-enhanced helical computed tomography ceCT and positron emission tomography PET with F-fluorodeoxyglucose FDG. The aim of this study was to compare the prognostic power of PET and ceCT and to evaluate the clinical role of PET-CT imaging.

MethodsAll patients with GIST undergoing PET or PET-CT examinations were prospectively included in this study, and the median overall survival, time to progression and treatment duration were documented. The prognostic significance of PET and ceCT criteria of treatment response was assessed and PET-CT was compared with PET and ceCT imaging. Data for 34 patients 19 male, 15 female, 21–76 years undergoing PET or PET-CT for staging or restaging were analysed.

ResultsIn 28 patients, PET-CT and ceCT were available after introduction of treatment with the tyrosine kinase inhibitor imatinib mesylate Gleevec; Novartis, Basel, Switzerland. Patients without FDG uptake after the start of treatment had a better prognosis than patients with residual activity. In contrast, ceCT criteria provided insufficient prognostic power. However, more lesions were found on ceCT images than on PET images, and FDG uptake was sometimes very variable. PET-CT delineated active lesions better than did the combination of PET and ceCT imaging.

ConclusionBoth PET and PET-CT provide important prognostic information and have an impact on clinical decision-making in GIST patients. PET-CT precisely delineates lesions and thus allows for the correct planning of surgical interventions.

KeywordsGIST Treatment response Molecular imaging FDG PET Image co-registration  Download fulltext PDF



Autor: G. W. Goerres - R. Stupp - G. Barghouth - T. F. Hany - B. Pestalozzi - E. Dizendorf - P. Schnyder - F. Luthi - G. K. v

Fuente: https://link.springer.com/







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