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BMC Gastroenterology

, 5:11

First Online: 24 March 2005Received: 31 August 2004Accepted: 24 March 2005

Abstract

BackgroundIn primary biliary cirrhosis PBC and primary sclerosing cholangitis PSC fatigue is a major clinical problem. Abnormal amino acid AA patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify abnormalities in AA patterns and to define their relation with fatigue.

MethodsPlasma concentrations of tyrosine, tryptophan, phenylalanine, valine, leucine and isoleucine were determined in plasma of patients with PBC n = 45, PSC n = 27, chronic hepatitis C n = 22 and healthy controls n = 73. Fatigue and quality of life were quantified using the Fisk fatigue severity scale, a visual analogue scale and the SF-36.

ResultsValine, isoleucine, leucine were significantly decreased in PBC and PSC. Tyrosine and phenylalanine were increased p < 0.0002 and tryptophan decreased p < 0.0001 in PBC. In PBC, but not in PSC, a significant inverse relation between tyrosine concentrations and fatigue and quality of life was found. Patients without fatigue and with good quality of life had increased tyrosine concentrations compared to fatigued patients. Multivariate analysis indicated that this relation was independent from disease activity or severity or presence of cirrhosis.

ConclusionIn patients with PBC and PSC, marked abnormalities in plasma AA patterns occur. Normal tyrosine concentrations, compared to increased concentrations, may be associated with fatigue and diminished quality of life.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-230X-5-11 contains supplementary material, which is available to authorized users.

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Autor: Pieter CJ ter Borg - Durk Fekkes - Jan Maarten Vrolijk - Henk R van Buuren

Fuente: https://link.springer.com/



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