A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in ThailandReportar como inadecuado




A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Malaria Journal

, 4:38

First Online: 14 August 2005Received: 19 May 2005Accepted: 14 August 2005

Abstract

BackgroundIL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T.

MethodsTo examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat VNTR were analysed in 312 Thai patients with malaria 109 cerebral malaria and 203 mild malaria patients.

ResultsIn this population, IL1B -31C>T and IL1RA VNTRwere detected, while IL1B 3953C>T i.e., IL1B 3953T was not observed in the polymorphism screening for 32 patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients showed no significant association of these polymorphisms with cerebral malaria.

ConclusionThe present results suggest that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria.

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Autor: Jun Ohashi - Izumi Naka - Akihiro Doi - Jintana Patarapotikul - Hathairad Hananantachai - Noppadon Tangpukdee - Sornchai Lo

Fuente: https://link.springer.com/



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