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Molecular Pain

, 1:22

First Online: 15 August 2005Received: 01 June 2005Accepted: 15 August 2005


Calcium-calmodulin-dependent protein kinase IV CaMKIV phosphorylates the major transcription factor cyclic AMP-response element binding protein CREB, which plays a role in emotional behavior. Here, CaMKIV knockout mice CaMKIV were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIVexhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.

Keywordsanxiety CaMKIV knockout mice microarray stress-induced analgesia Electronic supplementary materialThe online version of this article doi:10.1186-1744-8069-1-22 contains supplementary material, which is available to authorized users.

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Autor: Fanny WF Shum - Shanelle W Ko - Yong-Seok Lee - Bong-Kiun Kaang - Min Zhuo


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