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Breast Cancer Research

, 7:R922

First Online: 22 September 2005Received: 04 June 2005Revised: 25 August 2005Accepted: 06 September 2005

Abstract

IntroductionMammographic breast density is a strong independent risk factor for breast cancer. We hypothesized that demonstration of an association between mammographic breast density and bone mineral density BMD would suggest a unifying underlying mechanism influencing both breast density and BMD.

MethodsIn a cross-sectional analysis of baseline data from the Postmenopausal Estrogen-Progestin Interventions Study PEPI, participants were aged 45 to 64 years and were at least 1 year postmenopausal. Mammographic breast density percentage of the breast composed of dense tissue, the outcome, was assessed with a computer-assisted percentage-density method. BMD, the primary predictor, was measured with dual-energy X-ray absorptiometry. Women quitting menopausal hormone therapy to join PEPI were designated recent hormone users.

ResultsThe mean age of the 594 women was 56 years. The average time since menopause was 5.6 years. After adjustment for age, body mass index, and cigarette smoking, in women who were not recent hormone users before trial enrollment n = 415, mammographic density was positively associated with total hip P = 0.04 and lumbar P = 0.08 BMD. Mammographic density of recent hormone users n = 171 was not significantly related to either total hip P = 0.51 or lumbar P = 0.44 BMD. In participants who were not recent hormone users, mammographic density was 4% greater in the highest quartile of total hip BMD than in the lowest. In participants who were not recent hormone users, mammographic density was 5% greater in the highest quartile of lumbar spine BMD than in the lowest.

ConclusionMammographic density and BMD are positively associated in women who have not recently used postmenopausal hormones. A unifying biological mechanism may link mammographic density and BMD. Recent exogenous postmenopausal hormone use may obscure the association between mammographic density and BMD by having a persistent effect on breast tissue.

AbbreviationsBMDbone mineral density

PEPI-MDSPostmenopausal Estrogen-Progestin Interventions Mammographic Density Study

PEPIPostmenopausal Estrogen-Progestin Interventions Study.

Electronic supplementary materialThe online version of this article doi:10.1186-bcr1327 contains supplementary material, which is available to authorized users.

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Autor: Carolyn Crandall - Shana Palla - Beth A Reboussin - Giske Ursin - Gail A Greendale

Fuente: https://link.springer.com/







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