Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohns disease and ulcerative colitisReportar como inadecuado




Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohns disease and ulcerative colitis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Gastroenterology

, 5:31

First Online: 22 September 2005Received: 07 March 2005Accepted: 22 September 2005

Abstract

BackgroundUlcerative colitis UC and Crohn-s disease CD are characterized by intestinal inflammation mainly caused by a disturbance in the balance between cytokines and increased complement C activation. Our aim was to evaluate possible associations between C activation capacity and prednisolone treatment.

MethodsPlasma from patients with exacerbations of UC n = 18 or CD n = 18 were collected before and during high dose prednisolone treatment 1 mg-kg body weight and tapering. Friedman-s two way analysis of variance, Mann-Whitney U test and Wilcoxon signed-rank sum test were used

ResultsBefore treatment, plasma from CD patients showed significant elevations in all C-mediated analyses compared to the values obtained from 38 healthy controls p < 0.02, and in mannan binding lectin MBL-concentration and MBL-C4-activation capacity AC values compared to UC patients p < 0.02. Before treatment, plasma from UC patients showed significant elevations only in the classical pathway-mediated C3-AC compared to values obtained from healthy controls p < 0.01. After treatment was initiated, significant reductions, which persisted during follow-up, were observed in the classical pathway-mediated C3-AC and MBL-C4-AC in plasma from CD patients p < 0.05.

ConclusionOur findings indicate that C activation capacity is up-regulated significantly in plasma from CD patients. The decreases observed after prednisolone treatment reflect a general down-regulation in immune activation.

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Autor: Erik Zimmermann-Nielsen - Henning Grønbæk - Jens Frederik Dahlerup - Gunnar Baatrup - Ole Thorlacius-Ussing

Fuente: https://link.springer.com/



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