The effect of patient characteristics on variability in pain and function over two years in early knee osteoarthritisReportar como inadecuado

The effect of patient characteristics on variability in pain and function over two years in early knee osteoarthritis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Health and Quality of Life Outcomes

, 3:59

First Online: 27 September 2005Received: 23 March 2005Accepted: 27 September 2005


BackgroundLarge variations in pain and function are seen over time in subjects at risk for and with radiographic knee osteoarthritis OA. We hypothesized that this variation may be related not only to knee OA but also to patient characteristics. The objective of this study was to investigate the influence of age, gender, and body mass index BMI on clinically relevant change in pain and function over two years in subjects at high risk for or with knee OA.

MethodsWe assessed 143 individuals 16% women, mean age 50 years range 27–83 twice; 14 and 16 years after isolated meniscectomy. Subjects completed one disease-specific questionnaire, the Knee injury and Osteoarthritis Outcome Score KOOS and one generic measure, the SF-36. Individuals with a BMI between 25 and 29.9 were considered overweight, while individuals with a BMI of 30 or more were considered obese.

ResultsSubjects aged 46–56 the middle tertile were more likely to change ≥10 points on a 0–100 scale in the KOOS subscale Activities of Daily Living ADL than younger subjects odds ratio OR 4.5, 95% confidence interval 95% CI 1.5–13.0. Essentially the same result was obtained after adjusting for baseline values. Overweight or obesity was a risk factor for clinically relevant change for knee pain OR 2.4, 95% CI 1.0 – 5.8, OR 4.0, 95% CI 1.2 – 13.6 and obesity for change in ADL OR 4.3, 95% CI 1.2 – 15.4. The results did not remain significant when adjusted for the respective baseline value. Being symptomatic was strongly associated with increased variation in pain and function while presence or absence of radiographic changes did not influence change over two years in this cohort.

ConclusionIn a population highly enriched in early-stage and established knee OA, symptomatic, middle-aged, and overweight or obese subjects were more likely to vary in their knee function and pain over two years. The natural course of knee pain and function may be associated with subject characteristics such as age and BMI.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7525-3-59 contains supplementary material, which is available to authorized users.

Przemyslaw T Paradowski, Martin Englund contributed equally to this work.

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Autor: Przemyslaw T Paradowski - Martin Englund - L Stefan Lohmander - Ewa M Roos


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