Biology and physiology of Calbindin-D9k in female reproductive tissues: Involvement of steroids and endocrine disruptorsReportar como inadecuado




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Reproductive Biology and Endocrinology

, 3:66

First Online: 16 November 2005Received: 02 September 2005Accepted: 16 November 2005

Abstract

Although Calbindin-D9k CaBP-9k, a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity related with intracellular calcium level and is not under the control of vitamin D despite the presence of vitamin D receptors. But, it is under the control of the sex steroid hormones, estrogen E2 and progesterone P4, in female reproductive systems including the uterus and placenta. Thus, in this review, we summarize recent research literature in regards to the expression and regulation of CaBP-9k in mammals and introduce the research data of recent studies by us and others.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7827-3-66 contains supplementary material, which is available to authorized users.

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Autor: Kyung-Chul Choi - Peter CK Leung - Eui-Bae Jeung

Fuente: https://link.springer.com/







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