MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteinsReportar como inadecuado




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Genome Biology

, 5:R21

First Online: 13 February 2004Received: 03 November 2003Revised: 17 December 2003Accepted: 08 January 2004

Abstract

We evaluated the evolutionary conservation of glycine myristoylation within eukaryotic sequences. Our large-scale cross-genome analyses, available as MYRbase, show that the functional spectrum of myristoylated proteins is currently largely underestimated. We give experimental evidence for in vitro myristoylation of selected predictions. Furthermore, we classify five membrane-attachment factors that occur most frequently in combination with, or even replacing, myristoyl anchors, as some protein family examples show.

Electronic supplementary materialThe online version of this article doi:10.1186-gb-2004-5-3-r21 contains supplementary material, which is available to authorized users.

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Autor: Sebastian Maurer-Stroh - Masaki Gouda - Maria Novatchkova - Alexander Schleiffer - Georg Schneider - Fernanda L Sirota - Mi

Fuente: https://link.springer.com/



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