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Genome Biology

, 5:R14

First Online: 13 February 2004Received: 04 September 2003Revised: 12 November 2003Accepted: 09 January 2004

Abstract

BackgroundLong terminal repeat LTR retrotransposons make up a large fraction of the typical mammalian genome. They comprise about 8% of the human genome and approximately 10% of the mouse genome. On account of their abundance, LTR retrotransposons are believed to hold major significance for genome structure and function. Recent advances in genome sequencing of a variety of model organisms has provided an unprecedented opportunity to evaluate better the diversity of LTR retrotransposons resident in eukaryotic genomes.

ResultsUsing a new data-mining program, LTR STRUC, in conjunction with conventional techniques, we have mined the GenBank mouse Mus musculus database and the more complete Ensembl mouse dataset for LTR retrotransposons. We report here that the M. musculus genome contains at least 21 separate families of LTR retrotransposons; 13 of these families are described here for the first time.

ConclusionsAll families of mouse LTR retrotransposons are members of the gypsy-like superfamily of retroviral-like elements. Several different families of unrelated non-autonomous elements were identified, suggesting that the evolution of non-autonomy may be a common event. High sequence similarity between several LTR retrotransposons identified in this study and those found in distantly-related species suggests that horizontal transfer has been a significant factor in the evolution of mouse LTR retrotransposons.

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Autor: Eugene M McCarthy - John F McDonald

Fuente: https://link.springer.com/







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