Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigsReportar como inadecuado




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Lipids in Health and Disease

, 3:2

First Online: 18 February 2004Received: 22 January 2004Accepted: 18 February 2004

Abstract

IntroductionThere has been renewed interest in mushroom medicinal properties. We studied cholesterol lowering properties of Ganoderma lucidum Gl, a renowned medicinal species.

ResultsOrganic fractions containing oxygenated lanosterol derivatives inhibited cholesterol synthesis in T9A4 hepatocytes. In hamsters, 5% Gl did not effect LDL; but decreased total cholesterol TC 9.8%, and HDL 11.2%. Gl 2.5 and 5% had effects on several fecal neutral sterols and bile acids. Both Gl doses reduced hepatic microsomal ex-vivo HMG-CoA reductase activity. In minipigs, 2.5 Gl decreased TC, LDL- and HDL cholesterol 20, 27, and 18%, respectively P < 0.05; increased fecal cholestanol and coprostanol; and decreased cholate.

ConclusionsOverall, Gl has potential to reduce LDL cholesterol in vivo through various mechanisms. Next steps are to: fully characterize bioactive components in lipid soluble-insoluble fractions; evaluate bioactivity of isolated fractions; and examine human cholesterol lowering properties. Innovative new cholesterol-lowering foods and medicines containing Gl are envisioned.

Keywordscholesterol Ganoderma lucidum hamsters HDL LDL lipoprotein lovastatin minipigs mushrooms Reishi List of abbreviationsDday

FPLCfast protein liquid chromatography

GCgas chromatography

HPLChigh pressure liquid chromatography

TLCthin layer chromatography

TAGtriacylglycerol

TCtotal cholesterol.

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Autor: A Berger - D Rein - E Kratky - I Monnard - H Hajjaj - I Meirim - C Piguet-Welsch - J Hauser - K Mace - P Niederberger

Fuente: https://link.springer.com/







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