The Prevention of Hereditary Breast and Ovarian Cancer: A Personal ViewReportar como inadecuado

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Hereditary Cancer in Clinical Practice

, 2:5

First Online: 20 February 2004Received: 09 February 2004Accepted: 15 February 2004


Options for the prevention of hereditary breast and ovarian cancer include screening, preventive surgery and chemoprevention. Screening studies with magnetic resonance imaging of the breast are promising but the technology is not widespread and MRI is unlikely to be available as a screening tool in the near future. Prophylactic oophorectomy and mastectomy are effective preventive measures and are gaining in acceptance by patients and physicians. Preventive mastectomy is effective against both primary and contralateral breast cancer. Oophorectomy prevents ovarian cancer, and if done prior to menopause, will prevent breast cancer as well. Tamoxifen has been shown to prevent contralateral breast cancers in BRCA1 and BRCA2 carriers but is not widely accepted as a means of primary prevention. Oral contraceptives and tubal ligation will reduce the risk of hereditary ovarian cancer and should be considered in women who wish to retain ovarian function.

KeywordsBRCA1 BRCA2 breast cancer ovarian cancer chemoprevention  Download fulltext PDF

Autor: Steven Narod


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