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Hereditary Cancer in Clinical Practice

, 2:99

First Online: 18 May 2004Received: 14 May 2004Accepted: 15 May 2004


We report three Dutch families with familial clustering of preneoplastic cervical disease, review the literature on familial risks of cervical intraepithelial neoplasia CIN and cervical cancer, and discuss possible practical guidelines for women with a family history of cervical cancer. Daughters and sisters of women with cervical cancer have been reported to have a relative risk of 1.5-2.3 to develop this type of cancer. From a practical clinical point of view, we suggest that as in women with an increased non-genetic risk to develop cervical cancer e.g. because of immunosuppressive therapy increased surveillance to detect this tumour should be considered in women with an increased risk based on family history. Cessation of smoking should be advised. As the use of condoms at least prevents HPV re-infection its use can be recommended as a way to lower the cervical cancer risk. Future studies to determine the genetic contribution to the development of cervical cancer should include the paternal family history of cancer and, because genetic predisposition might express itself as a higher risk to develop precursors of cervical cancer, carcinoma in situ and CIN grade II-III.

Keywordscervical cancer familial family history risk screening  Download fulltext PDF

Autor: Margreet Zoodsma - Rolf H Sijmons - Elisabeth GE de Vries - Ate GJ van der Zee

Fuente: https://link.springer.com/

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