Atherosclerotic renal artery stenosis: one year outcome of total and separate kidney function following stentingReportar como inadecuado

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BMC Nephrology

, 5:15

First Online: 15 October 2004Received: 14 June 2004Accepted: 15 October 2004


BackgroundRenal artery stenosis RAS is a known cause of hypertension and ischemic nephropathy. Stenting of the artery is a valid approach, in spite of cases of unexpected adverse evolution of renal function.

MethodsIn this study, 27 patients with unilateral RAS were subjected to stenting and followed for a period of one year, while 19 patients were observed while on medical treatment only. The group of 27 patients, 67.33 ± 6.8 years of age, creatinine of 2.15 ± 0.9 mg-dl, following stenting, were followed at intervals with biochemical tests, renal scintigraphy and doppler ultrasonography. The control group 70.0 ± 6.1 years, creatinine 1.99 ± 0.7 mg-dl was also followed for one year.

ResultOne year after stenting mean creatinine clearance Ccr increased from 36.07 ± 17.2 to 40.4 ± 21.6 ml-min NS. Arterial BP, decreased after 1,3,6, and 12 months p < 0.05. The number of antihypertensive drugs also decreased p < 0.05. A significant increase in proteinuria was also observed. In the control group both Ccr, BP and proteinuria did not show significant changes. Based on renal scintigraphy and Ccr at subsequent times, it was possibile to evaluate the timecourse of renal function in both kidneys of the stented patients. In the stented kidneys Ccr increased significantly. On the controlateral kidney a decrease of renal function p < 0.05 was observed. Resistance index appeared to be a risk factor of the functional outcome.

ConclusionsStenting of RAS due to atherosclerosis is followed by stabilization or improvement of Ccr, mainly at the stented kidney, while contralateral renal function showed a decrease.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2369-5-15 contains supplementary material, which is available to authorized users.

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Autor: Giorgio Coen - Eleonora Moscaritolo - Carlo Catalano - Raffaella Lavini - Italo Nofroni - Giuseppe Ronga - Daniela Sardella


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