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Abstract: We report on a theoretical study showing that the leak conductance density,$\GL$, in the squid giant axon appears to be optimal for the action potentialfiring frequency. More precisely, the standard assumption that the leak currentis composed of chloride ions leads to the result that the experimental valuefor $\GL$ is very close to the optimal value in the Hodgkin-Huxley model whichminimizes the absolute refractory period of the action potential, therebymaximizing the maximum firing frequency under stimulation by sharp, brief inputcurrent spikes to one end of the axon. The measured value of $\GL$ also appearsto be close to optimal for the frequency of repetitive firing caused by aconstant current input to one end of the axon, especially when temperaturevariations are taken into account. If, by contrast, the leak current is assumedto be composed of separate voltage-independent sodium and potassium currents,then these optimizations are not observed.



Autor: Jeffrey Seely, Patrick Crotty

Fuente: https://arxiv.org/







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