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Respiratory Research

, 4:1

First Online: 15 May 2003Received: 30 August 2002Revised: 06 January 2003Accepted: 14 January 2003


Measurement of the effects of drugs, mediators and infectious agents on various models of lung disease, as well as assessment of lung function in the intact mouse has the potential for significantly advancing our knowledge of lung disease. However, the small size of the mouse presents significant challenges for the assessment of lung function. Because of compromises made between precision and noninvasiveness, data obtained may have an uncertain bearing on the mechanical response of the lung. Nevertheless, considerable recent progress has been made in developing valid and useful measures of mouse lung function. These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease.

airway animal models of disease asthma forced oscillation lung mechanics mouse Abbreviationsbpmbreaths per minute

Cdyndynamic compliance

CLlung compliance


FOTforced oscillation technique

FRCfunctional residual capacity

Gtissue damping or tissue resistance


MLImean linear intercept


Presresistive pressure

Pelelastic pressure

Pininertial pressure

Penhenhanced pause


TLCtotal lung capacity

UPunrestrained plethysmography

Open image in new windowFlow

ZRS or Zimpedance of the respiratory system

|Zrs|Magnitude of impedance

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Autor: Charles G Irvin - Jason HT Bates


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