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Reproductive Biology and Endocrinology

, 1:94

First Online: 10 November 2003Received: 14 April 2003Accepted: 10 November 2003


Chemokines are small molecular weight peptides responsible for adhesion, activation, and recruitment of leukocytes into tissues. Leukocytes are thought to influence follicular atresia, ovulation, and luteal function. Many studies in recent years have focused attention on the characterization of leukocyte populations within the ovary, the importance of leukocyte-ovarian cell interactions, and more recently, the mechanisms of ovarian leukocyte recruitment. Information about the role of chemokines and leukocyte trafficking chemotaxis during ovarian function is important to understanding paracrine-autocrine relationships shared between reproductive and immune systems. Recent advances regarding chemokine expression and leukocyte accumulation within the ovulatory follicle and the corpus luteum are the subject of this mini-review.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7827-1-94 contains supplementary material, which is available to authorized users.

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Autor: David H Townson - Amy R Liptak


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