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Reproductive Biology and Endocrinology

, 1:88

First Online: 10 November 2003Received: 29 April 2003Accepted: 10 November 2003


The corpus luteum CL is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor VEGF has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.

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Autor: Hamish M Fraser - Christine Wulff


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