Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival healthReportar como inadecuado

Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival health - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Oral Health

, 2:2

First Online: 12 February 2002Received: 12 October 2001Accepted: 12 February 2002


BackgroundAcidogenic, acid-tolerant bacteria induce dental caries and require D-alanyl glycerol lipoteichoic acid D-alanyl LTA on their cell surface. Because fluoride inhibits acid-mediated enamel demineralization, an elevated antibody response to D-alanyl LTA may indicate subjects with more acidogenic bacteria and, therefore, an association of DMFT with fluoride exposure and gingival health not apparent in low responders.

MethodsCluster analysis was used to identify low antibody content. Within low and high responders control and test subjects, the number of teeth that were decayed missing and filled DMFT, or decayed only DT were regressed against fluoride exposure in the water supply and from dentrifice use. The latter was determined from gingival health: prevalences of plaque PL and bleeding on probing BOP, and mean pocket depth PD. Age was measured as a possible confounding cofactor.

ResultsIn 35 high responders, DMFT associated with length of exposure to fluoridated water F score, PL and BOP R = 0.51, p < 0.001, whereas in 67 low D-ala-IgG responders, DMFT associated with PL, age, and PD R = 0.26, p < 0.001. BOP correlated strongly with number of 7 7 decayed teeth DT in 54 high responders R = 0.57, p < 0.001, but poorly in 97 low responders R = 0.12, p < 0.001. The strength of the PD association with DMFT, or of BOP with DT, in high responders significantly differed from that in low responders p < 0.05.

ConclusionCaries associates with gingival health and fluoridated water exposure in high D-alanyl LTA antibody responders.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6831-2-2 contains supplementary material, which is available to authorized users.

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Autor: Martin Levine - Robert L Brumley - Kevin T Avery - Willis L Owen - Donald E Parker

Fuente: https://link.springer.com/

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