The enhancement of the hyperglycemic effect of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine by vitamin C in an animal modelReportar como inadecuado




The enhancement of the hyperglycemic effect of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine by vitamin C in an animal model - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Pharmacology

, 2:18

First Online: 13 September 2002Received: 18 March 2002Accepted: 13 September 2002

Abstract

BackgroundS-nitrosoglutathione GSNO and S-nitroso-N-acetlypenicillamine SNAP are two of the most common sources of nitric oxide NO in the biomedical field. Vitamin C has been known to accelerate the decomposition of GSNO and SNAP increasing the release and availability of NO which is cytotoxic at non-physiological concentrations. The study investigates any potential detrimental effect of vitamin C and GSNO, vitamin C and SNAP on glucose metabolism in normotensive and normoglycemic dogs.

ResultsThe results showed that administration of vitamin C 50 mg-kg and GSNO 35 mg-kg and 50 mg-kg, or vitamin C 50 mg-kg and SNAP 10 mg-kg to overnight fasted dogs resulted in significant elevation of the blood glucose levels, attaining maximum level at the 2.0 or 2.5 h time point postprandially. The elevated blood glucose levels were due to significant reduction in plasma insulin levels in the dogs treated with vitamin C and GSNO, or vitamin C and SNAP P < 0.05. The decreased insulin response was associated with significant elevation of nitric oxide produced from GSNO and SNAP co-administered with vitamin C, as assessed by plasma nitrate-nitrite levels.

ConclusionsThe results indicate that enhanced NO release by vitamin C affects postprandial blood glucose and plasma insulin levels and the reduced glucose tolerance is mainly due to impaired insulin release. The clinical relevance of the findings of this study suggest that hypertensive diabetic patients treated with GSNO or SNAP, who are on vitamin C supplements may be more predisposed to further decrease in their glycemic control.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2210-2-18 contains supplementary material, which is available to authorized users.

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Autor: Donovan McGrowder - Dalip Ragoobirsingh - Tara Dasgupta

Fuente: https://link.springer.com/







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