Lack of association between estrogen receptor β dinucleotide repeat polymorphism and autoimmune thyroid diseases in Japanese patientsReportar como inadecuado




Lack of association between estrogen receptor β dinucleotide repeat polymorphism and autoimmune thyroid diseases in Japanese patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medical Genetics

, 2:1

First Online: 31 January 2001Received: 19 December 2000Accepted: 31 January 2001

Abstract

BackgroundThe autoimmune thyroid diseases AITDs, such as Graves- disease GD and Hashimoto-s thyroiditis HT, appear to develop as a result of complex interactions between predisposing genes and environmental triggers. Susceptibility to AITDs is conferred by genes in the human leukocyte antigen HLA and genes unlinked to HLA, including the CTLA-4 gene. Recently, estrogen receptor ER β, located at human chromosome 14q23-24.1, was identifed. We analyzed a dinucleotide CAn repeat polymorphism located in the flanking region of ERβ gene in patients with AITDs and in normal subjects. High heterozygosity makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems. We also correlated a ERβ gene microsatellite polymorphism with bone mineral density BMD in the distal radius and biochemical markers of bone turnover in patients with GD in remission.

ResultsFourteen different alleles were found in 133 patients with GD, 114 patients with HT, and 179 controls subjects. The various alleles were designated as allele1 through allele14 according to the number of the repeats, from 18 to 30. There was no significant difference in the distributions of ERβ alleles between patient groups and controls. Although recent study demonstrated a significant relation between a allele9 in the ERβ gene and BMD in postmenopausal Japanese women, there were no statistically significant interaction between this allele and BMD in the distal radius, nor biochemical markers in patients with GD in remission.

ConclusionsThe present results do not support an association between the ERβ microsatellite marker and AITD in the Japanese population. We also suggest that the ERβ microsatellite polymorphism has at most a minor pathogenic importance in predicting the risk of osteoporosis as a complication of GD.

Download fulltext PDF



Autor: Yoshiyuki Ban - Teruaki Tozaki - Matsuo Taniyama - Motowo Tomita - Yoshio Ban

Fuente: https://link.springer.com/







Documentos relacionados