Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonistsReportar como inadecuado




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Respiratory Research

, 2:66

First Online: 19 February 2001Received: 06 December 2000Accepted: 08 January 2001

Abstract

Interleukin-4 IL-4 mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 VCAM-1, promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release. Asthma is a complex genetic disorder that has been linked to polymorphisms in the IL-4 gene promoter and proteins involved in IL-4 signaling. Soluble recombinant IL-4 receptor lacks transmembrane and cytoplasmic activating domains and can therefore sequester IL-4 without mediating cellular activation. We report the results of initial clinical trials, which demonstrate clinical efficacy of this naturally occurring IL-4 antagonist as a therapeutic agent in asthma.

Keywordsasthma genetics soluble recombinant human interleukin-4 receptor T helper lymphocytes AbbreviationsFEV1forced expiratory volume in 1 second

GCRglucocorticoid receptor

ILinterleukin

IL-4Rinterleukin-4 receptor

IRSinsulin receptor substrate

rhuIL-4Rsoluble recombinant human interleukin-4 receptor

Statsignal transducer and activator of transcription

VCAMvascular cell adhesion molecule.

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Autor: John W Steinke - Larry Borish

Fuente: https://link.springer.com/







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