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Respiratory Research

, 2:61

First Online: 21 February 2001Received: 31 January 2001Accepted: 02 February 2001


The pathogenesis of cryptogenic fibrosing alveolitis CFA involves injury, an immune-inflammatory response and fibrosis. The cause of the injury is unknown, but the identification of serum autoantibodies makes an autoimmune aetiology attractive. The core study on which this commentary is based used novel cloning and serum screening technologies in order to identify new public and private autoantibodies in sera from 12 patients with CFA. Largely negative conclusions were drawn from that study. However, we suggest that the prevalence of autoantibodies may have been underestimated, that the study was timely and that this approach is worth pursuing further.

Keywordsautoantibodies cryptogenic fibrosing alveolitis expression libraries idiopathic pulmonary fibrosis pathogenesis AbbreviationsCFAcryptogenic fibrosing alveolitis

SEREXserologic identification by recombinant expression cloning

ThT-helper cell.

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Autor: Suveer Singh - Ron du Bois


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