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Respiratory Research

, 3:8

First Online: 19 November 2001Received: 24 April 2001Revised: 14 August 2001Accepted: 21 August 2001

Abstract

Pulmonary embolism PE is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a -milder- genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.

Pulmonary embolism PE is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a -milder- genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.

KeywordsFV Leiden genetics pulmonary embolism venous thrombosis AbbreviationsDVTdeep vein thrombosis

FVfactor V

PEpulmonary embolism

VTEvenous thromboembolism.

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Autor: W Craig Hooper - Christine De Staercke

Fuente: https://link.springer.com/







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